N-4 Alkyl Cytosine Derivatives Synthesis: A New Approach

The selective N-4 alkylation of cytosine plays a critical role in the synthesis biologically active molecules. This work focuses on development practical reaction conditions toward regioselective N-4-alkyl derivatives. sequence includes direct and sulfonylation at N-1 site cytosine, followed by amino using KHMDS CH2Cl2/THF mixture, providing fast efficient approach consistent with pyrimidine-based drug design.